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1

Epigenome-wide association studies for common human diseases

Rakyan, Vardhman K., Down, Thomas A., Balding, David J., Beck, Stephan

Journal:

Nature Reviews Genetics

Year:

2011

Language:

english

File:

PDF, 440 KB

english, 2011

2

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Down, Thomas A, Rakyan, Vardhman K, Turner, Daniel J, Flicek, Paul, Li, Heng, Kulesha, Eugene, Gräf, Stefan, Johnson, Nathan, Herrero, Javier, Tomazou, Eleni M

Journal:

Nature Biotechnology

Year:

2008

Language:

english

File:

PDF, 984 KB

english, 2008

3

Metastable epialleles in mammals

Vardhman K Rakyan, Marnie E Blewitt, Riki Druker, Jost I Preis, Emma Whitelaw

Journal:

Trends in Genetics

Year:

2002

Language:

english

File:

PDF, 47 KB

english, 2002

4

Transgenerational inheritance of non-genetically determined phenotypes

Holland, Michelle L., Rakyan, Vardhman K.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 423 KB

english, 2013

5

[Society of Petroleum Engineers Abu Dhabi International Petroleum Exhibition & Conference - Abu Dhabi, UAE (2017-11-13)] Abu Dhabi International Petroleum Exhibition & Conference - Integrated Deployment of Digital Oil Field in Multiple Kuwait Areas in One Platform and Benefits Realized

Al-Rakyan, Sara, Marie, Omar Abu, Ledesma, Fernando, Heshmat, Kareem, Mohamed, Assem, Zahourdin, Mohamed

Language:

english

File:

PDF, 1.08 MB

english

6

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

Bell, Christopher G., Finer, Sarah, Lindgren, Cecilia M., Wilson, Gareth A., Rakyan, Vardhman K., Teschendorff, Andrew E., Akan, Pelin, Stupka, Elia, Down, Thomas A., Prokopenko, Inga, Morison, Ian M.

Journal:

Year:

2010

Language:

english

File:

PDF, 361 KB

english, 2010

7

The hunt for the epiallele

Sarah Finer, Michelle L. Holland, Lisa Nanty, Vardhman K. Rakyan

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 397 KB

english, 2011

8

Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis

Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottav

Journal:

BMC Medical Genomics

Year:

2008

Language:

english

File:

PDF, 4.68 MB

english, 2008

9

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

Christopher G Bell, Andrew E Teschendorff, Vardhman K Rakyan, Alexander P Maxwell, Stephan Beck, David A Savage

Journal:

BMC Medical Genomics

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

10

Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells

Van Der Weyden, Louise, Rakyan, Vardhman, Luttrell, Brian M, Morris, Michael B, Conigrave, Arthur D

Journal:

Immunology & Cell Biology

Year:

2000

Language:

english

File:

PDF, 344 KB

english, 2000

11

DNA methylation profiling of human chromosomes 6, 20 and 22

Eckhardt, Florian, Lewin, Joern, Cortese, Rene, Rakyan, Vardhman K, Attwood, John, Burger, Matthias, Burton, John, Cox, Tony V, Davies, Rob, Down, Thomas A

Journal:

Nature Genetics

Year:

2006

Language:

english

File:

PDF, 362 KB

english, 2006

12

The methylome: approaches for global DNA methylation profiling

Stephan Beck, Vardhman K. Rakyan

Journal:

Trends in Genetics

Year:

2008

Language:

english

File:

PDF, 303 KB

english, 2008

13

Transgenerational epigenetic inheritance

Vardhman Rakyan, Emma Whitelaw

Journal:

Current Biology

Year:

2003

Language:

english

File:

PDF, 59 KB

english, 2003

14

Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes

Proudhon, Charlotte, Duffié, Rachel, Ajjan, Sophie, Cowley, Michael, Iranzo, Julian, Carbajosa, Guillermo, Saadeh, Heba, Holland, Michelle L., Oakey, Rebecca J., Rakyan, Vardhman K., Schulz, Reiner, B

Journal:

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

15

Epigenetic variation and inheritance in mammals

Vardhman K Rakyan, Stephan Beck

Journal:

Current Opinion in Genetics & Development

Year:

2006

Language:

english

File:

PDF, 170 KB

english, 2006

16

Sites of Differential DNA Methylation between Placenta and Peripheral Blood: Molecular Markers for Noninvasive Prenatal Diagnosis of Aneuploidies

Elisavet A. Papageorgiou, Heike Fiegler, Vardhman Rakyan, Stephan Beck, Maj Hulten, Klea Lamnissou, Nigel P. Carter, Philippos C. Patsalis

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 224 KB

english, 2009

17

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

Beyan, H., Down, T. A., Ramagopalan, S. V., Uvebrant, K., Nilsson, A., Holland, M. L., Gemma, C., Giovannoni, G., Boehm, B. O., Ebers, G. C., Lernmark, A., Cilio, C. M., Leslie, R. D., Rakyan, V. K.

Journal:

Genome Research

Year:

2012

Language:

english

File:

PDF, 882 KB

english, 2012

18

The hunt for mammalian epialleles

Vardhman Rakyan

Journal:

BMC Proceedings

Year:

2012

Language:

english

File:

PDF, 67 KB

english, 2012

19

Marmal-aid – a database for Infinium HumanMethylation450

Lowe, Robert, Rakyan, Vardhman K

Journal:

BMC Bioinformatics

Year:

2013

Language:

english

File:

PDF, 453 KB

english, 2013

20

Dipyrone misuse

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

21

Amoxicillin/clavulanic acid

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 127 KB

english, 2013

22

Daptomycin/linezolid/tigecycline

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

23

Batch traceability of unsafe biodrugs needs to improve

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 111 KB

english, 2013

24

Inactive or moderately active human promoters are enriched for inter-individual epialleles

Gemma, Carolina, Ramagopalan, Sreeram V, Down, Thomas A, Beyan, Huriya, Hawa, Mohammed I, Holland, Michelle L, Hurd, Paul J, Giovannoni, Gavin, David Leslie, R, Ebers, George C, Rakyan, Vardhman K

Journal:

Year:

2013

Language:

english

File:

PDF, 743 KB

english, 2013

25

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T. P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., Leslie, R. D., Deloukas, P., Spector, T. D.

Journal:

Genome Research

Year:

2010

Language:

english

File:

PDF, 480 KB

english, 2010

26

1032 Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study

Haesler, Robert, Feng, Zhe, Bäckdahl, Liselotte, Spehlmann, Martina E., Franke, Andre, Teschendorff, Andrew, Rakyan, Vardhman, Down, Thomas A., Wilson, Gareth A., Feber, Andrew, Beck, Stephan, Schreib

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 342 KB

english, 2013

27

Correcting for cell-type composition bias in epigenome-wide association studies

Robert Lowe,Vardhman K Rakyan

Journal:

Genome Medicine

Year:

2014

Language:

english

File:

PDF, 100 KB

english, 2014

28

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

Rakyan, V. K., Down, T. A., Thorne, N. P., Flicek, P., Kulesha, E., Graf, S., Tomazou, E. M., Backdahl, L., Johnson, N., Herberth, M., Howe, K. L., Jackson, D. K., Miretti, M. M., Fiegler, H., Marioni

Journal:

Genome Research

Year:

2008

Language:

english

File:

PDF, 1.03 MB

english, 2008

29

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates

Hillman, Sara L, Finer, Sarah, Smart, Melissa C, Mathews, Chris, Lowe, Robert, Rakyan, Vardhman K, Hitman, Graham A, Williams, David J

Journal:

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

30

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene: IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACE

Novakovic, B., Sibson, M., Ng, H. K., Manuelpillai, U., Rakyan, V., Down, T., Beck, S., Fournier, T., Evain-Brion, D., Dimitriadis, E., Craig, J. M., Morley, R., Saffery, R.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 3.17 MB

english, 2009

31

Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission

Rakyan, V. K., Chong, S., Champ, M. E., Cuthbert, P. C., Morgan, H. D., Luu, K. V. K., Whitelaw, E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 411 KB

english, 2003

32

A functional methylome map of ulcerative colitis

Hasler, R., Feng, Z., Backdahl, L., Spehlmann, M. E., Franke, A., Teschendorff, A., Rakyan, V. K., Down, T. A., Wilson, G. A., Feber, A., Beck, S., Schreiber, S., Rosenstiel, P.

Journal:

Genome Research

Year:

2012

Language:

english

File:

PDF, 517 KB

english, 2012

33

The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues

Lowe, Robert, Slodkowicz, Greg, Goldman, Nick, Rakyan, Vardhman K

Journal:

Year:

2015

Language:

english

File:

PDF, 2.35 MB

english, 2015

34

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

Finer, S., Mathews, C., Lowe, R., Smart, M., Hillman, S., Foo, L., Sinha, A., Williams, D., Rakyan, V. K., Hitman, G. A.

Journal:

Human Molecular Genetics

Year:

2015

Language:

english

File:

PDF, 369 KB

english, 2015

35

The promise and challenges of blood spot methylomics

Ramagopalan, Sreeram V, Rakyan, Vardhman K

Journal:

Year:

2013

Language:

english

File:

PDF, 542 KB

english, 2013

36

Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex

Ottaviani, D., Lever, E., Mitter, R., Jones, T., Forshew, T., Christova, R., Tomazou, E. M., Rakyan, V. K., Krawetz, S. A., Platts, A. E., Segarane, B., Beck, S., Sheer, D.

Journal:

Genome Research

Year:

2008

Language:

english

File:

PDF, 775 KB

english, 2008

37

Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates

Nanty, L., Carbajosa, G., Heap, G. A., Ratnieks, F., van Heel, D. A., Down, T. A., Rakyan, V. K.

Journal:

Genome Research

Year:

2011

Language:

english

File:

PDF, 1.80 MB

english, 2011

38

DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta

Novakovic, B., Wong, N. C., Sibson, M., Ng, H.-K., Morley, R., Manuelpillai, U., Down, T., Rakyan, V. K., Beck, S., Hiendleder, S., Roberts, C. T., Craig, J. M., Saffery, R.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.91 MB

english, 2010

39

Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies

Lowe, Robert, Gemma, Carolina, Beyan, Huriya, Hawa, Mohammed I., Bazeos, Alexandra, Leslie, R. David, Montpetit, Alexandre, Rakyan, Vardhman K., Ramagopalan, Sreeram V.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.08 MB

english, 2013

40

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

Rakyan, Vardhman K., Beyan, Huriya, Down, Thomas A., Hawa, Mohammed I., Maslau, Siarhei, Aden, Deeqo, Daunay, Antoine, Busato, Florence, Mein, Charles A., Manfras, Burkhard, Dias, Kerith-Rae M., Bell,

Journal:

Year:

2011

Language:

english

File:

PDF, 293 KB

english, 2011

41

Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development

Lowe, Robert, Gemma, Carolina, Rakyan, Vardhman K, Holland, Michelle L

Journal:

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

42

Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts

Novakovic, B., Rakyan, V., Ng, H.K., Manuelpillai, U., Dewi, C., Wong, N.C., Morley, R., Down, T., Beck, S., Craig, J.M., Saffery, R.

Journal:

Molecular Human Reproduction

Year:

2008

Language:

english

File:

PDF, 932 KB

english, 2008

43

Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells

WEYDEN, LOUISE VAN DER, RAKYAN, VARDHMAN, LUTTRELL, BRIAN M, MORRIS, MICHAEL B, CONIGRAVE, ARTHUR D

Journal:

Immunology & Cell Biology

Year:

2000

Language:

english

File:

PDF, 336 KB

english, 2000

44

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

Feber, A., Wilson, G. A., Zhang, L., Presneau, N., Idowu, B., Down, T. A., Rakyan, V. K., Noon, L. A., Lloyd, A. C., Stupka, E., Schiza, V., Teschendorff, A. E., Schroth, G. P., Flanagan, A., Beck, S.

Journal:

Genome Research

Year:

2011

Language:

english

File:

PDF, 993 KB

english, 2011

45

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease

Kraiczy, J, Nayak, K, Ross, A, Raine, T, Mak, T N, Gasparetto, M, Cario, E, Rakyan, V, Heuschkel, R, Zilbauer, M

Journal:

Mucosal Immunology

Year:

2015

Language:

english

File:

PDF, 3.40 MB

english, 2015

46

Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms

Ke, Xiayi, Cortina-Borja, Mario, Silva, Bruno Cesar, Lowe, Robert, Rakyan, Vardhman, Balding, David

Journal:

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

47

Creating People's Awareness and Pushing Active Contribution. Case: Wider Public Engagement on Flood and Land Use Problems in Jakarta and Surroundings

Oppusunggu, Ruth E., Tantular, Rakyan

Journal:

Procedia - Social and Behavioral Sciences

Year:

2015

Language:

english

File:

PDF, 284 KB

english, 2015

48

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans

Lowe, Robert, Overhoff, Marita G., Ramagopalan, Sreeram V., Garbe, James C., Koh, James, Stampfer, Martha R., Beach, David H., Rakyan, Vardhman K., Bishop, Cleo L.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.56 MB

english, 2015

49

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

Holland, M. L., Lowe, R., Caton, P. W., Gemma, C., Carbajosa, G., Danson, A. F., Carpenter, A. A. M., Loche, E., Ozanne, S. E., Rakyan, V. K.

Journal:

Year:

2016

Language:

english

File:

PDF, 901 KB

english, 2016

50

The marks, mechanisms and memory of epigenetic states in mammals

RAKYAN, Vardhman K., PREIS, Jost, MORGAN, Hugh D., WHITELAW, Emma

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001